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Burkitts Lymphoma

Definition

Burkitt lymphoma is a form of cancer that primarily affects children living in certain areas of Africa. Burkitt lymphoma is also found in North America, but it is rare. Adults can also be affected.

What is going on in the body?

Burkitt lymphoma occurs when a specialized white blood cell called the B-lymphocyte undergoes cancerous changes. The cells begin to grow and multiply out of control. The cancerous cells form tumors. Burkitt lymphoma is aggressive. This means that once it develops, it can grow quickly.
There are two types of Burkitt lymphoma: the African form and the North American form. In the African form, tumors form under the jaw and in the abdomen. It is associated with an infection caused by the Epstein-Barr virus. This is a common virus, and most people recover from it. However, in African children, Epstein-Barr virus causes cells to turn cancerous. No one is sure why. One theory is that children who have had malaria, which is common in Africa, have weakened immune systems. This may make their bodies more likely to respond this way to an Epstein-Barr virus infection.
The North American form of Burkitt lymphoma affects the bone marrow. Epstein-Barr virus is not a factor in this form of the disease. In North America, Epstein-Barr infections are associated with mononucleosis.

Risks

What are the causes and risks of the disease?

The exact cause of Burkitt lymphoma is unknown. Burkitt lymphoma seems to happen most often in persons who first have had a condition that weakens their immune systems, such as malaria or AIDS. Then, when these people come down with Epstein-Barr virus, Burkitt lymphoma occurs.

Prevention

What can be done to prevent the disease?

Nothing can be done to prevent this cancer.

Diagnosed

How is the disease diagnosed?

Doctors diagnose the disease by analyzing a sample of cells from the swollen tissue in the jaw or abdomen. A piece of the swollen tissue, called a biopsy sample, is removed. Special stains and other tests are applied to the tissue. If these tests show Burkitt lymphoma, then the person will undergo other testing that helps the doctor figure out the extent of the cancer. This includes CT scans and a bone marrow biopsy.

Long Term Effects

What are the long-term effects of the disease?

Burkitt lymphoma is an aggressive cancer. Once it appears, the cancerous cells grow very quickly. If it is not treated, Burkitt lymphoma leads to death.

Other Risks

What are the risks to others?

There is no risk to others from a person with Burkitt lymphoma or any other cancer.

Treatments

What are the treatments for the disease?

Chemotherapy is the primary treatment because the disease is usually spread all over the body. Several different types of chemotherapy are given together. The Africa form is the most treatable. Cancer is said to be in remission, with no evidence of disease, when it has been successfully treated. The remission in Burkitt lymphoma may be long-lasting.

Side Effects

What are the side effects of the treatments?

The side effects depend on the medicines used to treat the cancer. After treatment is completed, the side effects go away. The most common side effects are nausea, fatigue, and being more likely to develop infections.

After Treatment

What happens after treatment for the disease?

After treatment, the person will have to be monitored closely to make sure that the cancer doesn't come back. It is usually necessary for the person to have close medical followup for the rest of his or her life.

Monitor

How is the disease monitored?

CT scans, special X-rays, and physical examination are used to monitor the body's response to treatment. These same tests are also used to check whether the disease has come back. Bloods tests, including a CBC, are used during treatment to monitor for side effects, such as low blood cell amounts.

Sources

Molina, A.;&Pezner, R.D.(1996). Non-Hodgkins lymphoma in Cancer Management: A Multidisciplinary Approach. PRR: Huntington, NY. Pp.226-256.

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