- celiac sprue
- nontropical sprue
- gluten-sensitive enteropathy
- gluten intolerance
Celiac disease is a
malabsorption syndrome. The intestine is not able to absorb vital dietary nutrients from foods, because of an immune reaction to gluten, a component in many foods.
What is going on in the body?
What are the causes and risks of the disease?
Celiac disease is not contagious. It has a genetic component, but the way it is inherited is not clear. Genetic counseling is useful for those at risk of passing it to their children. The risk for identical twins may be as high as 70%. The risk for other brothers and sisters is 10%. The risk for children of parents with celiac disease is 5-10%.
What can be done to prevent the disease?
There is no known way to prevent celiac disease.
Genetic testing may be useful in some cases.
How is the disease diagnosed?
Celiac disease may be diagnosed by observing the symptoms after an infant begins eating cereals. It is often diagnosed during the second year of life, though it can manifest later..A blood test may show impaired levels of carbohydrate absorption, or elevated levels of antibodies against certain body proteins.
Stool may be examined for excessive amounts of fat as this is a common sign of celiac disease. A healthcare provider may also order a
barium enema x-ray study of the small bowel to check for increased intestinal secretion and clumping of the barium in the bowel.
When celiac disease is suspected, a
biopsy of the small intestine may show an abnormal inner surface of the small intestine.
Long Term Effects
What are the long-term effects of the disease?
The long-term effects of celiac disease include:
- anemia, which is a reduction in the number of red blood cells circulating in the blood
- delayed growth
- bone loss. Bone loss can cause
osteomalaciain adults, with bone pain and tenderness. Bone loss in children is seen as rickets, with bowlegs, a protruding stomach and a pigeon breast in children.
- defects of the nervous system
- inflammation of the skin
- malignant lymphoma
What are the risks to others?
Celiac disease is not contagious. It is an inherited disease, but the way it is inherited is not clear.
Genetic counseling is useful for those at risk of passing it to their children. The risk for identical twins may be as high as 70%. The risk for other brothers and sisters is 10%. The risk for children of parents with celiac disease is 5-10%.
What are the treatments for the disease?
Many of the effects of celiac disease can be minimized with a special diet. People with celiac disease learn to avoid the proteins in cereal. The proteins in wheat, rye, barley, and oats cause the symptoms of the disease.
Some people may be able to tolerate oats, but oat products are frequently contaminated with wheat and thus cause symptoms. Oats should not be tested until initial recovery has occurred. Some people need therapy with steroid medications because dietary limitations are not enough to eliminate the symptoms.
What are the side effects of the treatments?
Use of steroids may cause
memory loss, bone loss, weight gain, congestive heart disease, or high blood pressure.
What happens after treatment for the disease?
Dietary restriction or drug therapy will be needed throughout the person's life.
How is the disease monitored?
Celiac disease is monitored by simple observation of symptoms.
King RA, Rotter JL and Motulsky AG: The Genetic Basis of Common Diseases. Oxford University Press, 1992.