- anti-GBM antibody disease
What is going on in the body?
What are the causes and risks of the disease?
The cause of Goodpasture syndrome is unknown. It is more commonly seen in people who
What can be done to prevent the disease?
How is the disease diagnosed?
- urinalysis and other urine tests, which can detect kidney damage
- a chest x-ray, which may show signs of swelling in the lungs
- a complete blood count, or CBC, to detect anemia, or a low red blood cell count
- kidney function tests, to see how badly the kidney has been damaged
- an antibody titer blood test, to see if abnormal antibodies are present
- a biopsy of the kidney. In this test, a tiny sliver of kidney tissue is obtained with a long needle inserted through the skin of the back, and examined for signs of damage to the small filters of the kidney
Long Term Effects
What are the long-term effects of the disease?
What are the risks to others?
What are the treatments for the disease?
- plasma exchange, or
plasmapheresis. This is a procedure in which the abnormal antibodies, along with other blood proteins, are filtered out of the blood. There are then fewer of these antibodies to cause damage to the kidneys and the lungs.
- steroids to treat inflammation in the lungs and kidneys
- immunosuppressive medications, such as cyclophosphamide (i.e., Cytoxa), to stop the white blood cells from making abnormal antibodies
What are the side effects of the treatments?
- Plasmapheresis may remove proteins that help the blood clot. This can lead to bleeding.
- Steroids and cyclophosphamide suppress the body's immune system. This means that the person is at higher risk for infections.
- Cyclophosphamide can sometimes cause bleeding from the bladder. Drinking large amounts of fluids helps to reduce this risk.
What happens after treatment for the disease?
How is the disease monitored?
Isselbacher KJ, Braunwald E, Wilson, JD, et al: Harrison's principles of internal medicine. ed 13; p1309. New York, 1994, McGraw-Hill